Analytical Methods for Therapeutic Drug Monitoring and Toxicology Q. Alan Xu, Timothy L. Madden
Publisher: Wiley

In this investigation a DBS analytical approach is developed for the routine monitoring of caffeine, used to treat Apnea of Prematurity (AoP) in neonates, that is, children less than 1 month old. Advances in instrumental techniques [2] have enabled the analysis of DBS samples to be expanded to include therapeutic drug monitoring [3, 4], paediatric pharmacokinetic (PK) studies [5–8], and metabolite identification investigations [9, 10]. He is an internationally Recently, he developed several methods concerning therapeutic drug monitoring of clinically relevant drugs (i.e., immunosuppressants) using LC-MS-MS. His scientific interests include the pharmacology and toxicology of illicit drugs and their active metabolites, and the application of modern analytical methods (particularly liquid chromatography-mass spectrometry [LC-MS]) in clinical and forensic toxicology. Therapeutic Drug Monitoring: A Concise Guide. Analytical Methods for Therapeutic Drug Monitoring and Toxicology by Q. Therapeutic drug monitoring is a branch of clinical chemistry that specializes in the measurement of medication levels in blood. Its main focus is on drugs with a narrow therapeutic range, i.e. The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques. This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. Analytical Methods for Therapeutic Drug Monitoring and Toxicology English | 2011 | ISBN: 0470455616 | PDF | 520 pages | 5.7 MB Analytical Methods for Therapeutic Drug Monitoring and Toxic.